Rosaria Volpini | International School of Advanced Studies Unicam

short CV

bio

Rosaria Volpini was born in Camerino, Italy, in 1962. She received the Medicinal Chemistry and Technology degree (summa cum laude, 1990), Pharmacy degree (summa cum laude, 1995) and the Ph.D degree (1994) from the University of Camerino. In 1994 she was a doctoral fellow at the School of Chemistry, University of Birmingham (UK). From 1995 to 1999 R. Volpini worked as Research Fellow, then she got the position of Associate Researcher and Charged Professor of Medicinal Chemistry (1999-2005) at the Department of Chemical Sciences, Faculty of Pharmacy, University of Camerino. In 2005 she became Associate Professor and from 2010 she is full Professor of Medicinal Chemistry. Her scientific production focuses on the synthesis of nucleosides, nucleotides and heterocycles and on the study of their biological activity as agonists and antagonists of the P1 and P2 purinergic receptors, platelet aggregation inhibitors, antiviral and antitumor agents, and enzyme inhibitors. She published 124 scientific papers in international journals and presented over than 200 communications to meetings. Among her scientific publications there is a special issue on Purinergic Receptors that she edited as editor and author. She is member of the editorial board of International Journal of Medicinal Chemistry and member of International Society of Nucleosides, Nucleotides and Nucleic Acid, Italian Chemical Society Medicinal Chemistry Division, and Italian Purine Club.

research topics

Among her research activity most relevant results are a series of A_2A adenosine receptor antagonists with purine structure which showed very high activity in different animal models of Parkinson’s disease and represent a new approach to the therapy of such pathology. Another important result of her research activity are a number of adenosine derivatives which are the most potent and selective of A₃ adenosine receptor agonists reported so far potentially useful as anti-inflammatory and antitumor agents.

selected publications

C. Lambertucci, D. Dal Ben, M. Buccioni, G. Marucci, A. Thomas, R. Volpini “Medicinal Chemistry of P2X Receptors: Agonists and Orthosteric Antagonists”. Curr. Med. Chem., 22, 915-928, 2015.

C. Lambertucci, M. Buccioni, D. Dal Ben, S. Kachler, G. Marucci, A. Spinaci, A. Thomas, K.-N. Klotz, R. Volpini “New substituted 9-propyladenine derivatives as A_2A adenosine receptor antagonists”. Med. Chem. Commun., 6, 963-970, 2015.

D. Dal Ben, M. Buccioni, C. Lambertucci, S. Kachler, N. Falgner, G. Marucci, A. Thomas, G. Cristalli, R. Volpini, K.-N. Klotz “Different efficacy of adenosine and NECA derivatives at the human A₃ adenosine receptor: Insight into the receptor activation switch”. Biochem. Pharmacol., 87, 24-38, 2014.

C. Lambertucci, M. Sundukova, D. D. Kachare, D. S. Panmand, D. Dal Ben, M. Buccioni, G. Marucci, A. Marchenkova, A. Thomas, A. Nistri, G. Cristalli, R. Volpini “Evaluation of adenine as scaffold for the development of novel P2X3 receptor antagonists”. Eur. J. Med. Chem., 65, 41-50, 2013.

R. Volpini, G. Marucci, M. Buccioni, D. Dal Ben, C. Lambertucci, C. Lammi, R. C. Mishra, A. Thomas, G. Cristalli “Evidence for the Existence of a Specific G Protein-Coupled Receptor Activated by Guanosine”. Chem. Med. Chem, 6 (6), 1074-1080, 2011. VIP (Very Important Paper): “The paper was judged to be very important by the referees.”

E. Calleri, S. Ceruti, G. Cristalli, C. Martini, C. Temporini, C. Parravicini, R. Volpini, S. Daniele, G. Caccialanza, D. Lecca, C. Lambertucci, M. L. Trincavelli, G. Marucci, I. W. Wainer, G. Ranghino, P. Fantucci, M. P. Abbracchio, G. Massolini “Frontal Affinity Chromatography-Mass Spectrometry Useful for Characterization of New Ligands for GPR17 Receptor”. J. Med. Chem., 53, 3489-3501, 2010.

C. Roseti, E. Palma, K. Martinello, S. Fucule, R. Morace, V. Esposito, G. Cantore, A. Arcella, F. Giangaspero, E. Aronica, A. Mascia, G. Di Gennaro, P. P. Quarato, M. Manfredi, G. Cristalli, C. Lambertucci, G. Marucci, R. Volpini, C. Limatola, F. Eusebi “Blockage of A_2A and A₃ adenosine receptors decreases the desensitization of human GABA_A receptors microtransplanted to Xenopus oocytes”. PNAS, 106 (37), 15927-15931, 2009.

R. C. Spitale, R. Volpini, M. V. Mungillo, J. Krucinska, G. Cristalli, J. E. Wedekind “Single-Atom Imino Substitutions at A9 and A10 Reveal Distinct Effects on the Fold and Function of the Hairpin Ribozyme Catalytic Core”. Biochemistry, 48(33), 7777-7779, 2009.

R. Volpini, M. Buccioni, D. Dal Ben, C. Lambertucci, C. Lammi, G. Marucci, A. T. Ramadori, K.-N.Klotz, G. Cristalli. “Synthesis and Biological Evaluation of 2-Alkynyl-N⁶-methyl-5'-N-methylcarboxamidoadenosine Derivatives as Potent and Highly Selective Agonists for the Human Adenosine A₃ Receptor”. J. Med. Chem., 52(23), 7897-7900, 2009.

R. Volpini, D. Dal Ben, C. Lambertucci, G. Marucci, R. C. Mishra, A. T. Ramadori, K.-N.Klotz, M. L. Trincavelli, C. Martini, G. Cristalli. “Adenosine A_2A receptor antagonists: new 8-substituted 9-ethyladenines as tools for in vivo rat models of Parkinson’s disease”. Chem. Med. Chem., 4(6), 1010-1019, 2009.

R. Volpini, R. C. Mishra, D. D. Kachare, D. Dal Ben, C. Lambertucci, I. Antonini, S. Vittori, G. Marucci, E. Sokolova, A. Nistri, G. Cristalli. “Adenine based acyclic-nucleotides as novel P2X₃receptor ligands”. J. Med. Chem., 52, 4596-4603, 2009.

T. Borrmann, A. Abdelrahman, R. Volpini, C. Lambertucci, E. Alksnis, S. Gorzalka, M. Knospe, A. C. Schiedel, G. Cristalli, C. E. Mueller “Structure-Activity Relationships of Adenine and Deazaadenine Derivatives as Ligands for Adenine Receptors, a New Purinergic Receptor Family”. J. Med. Chem., 52 (19), 5974-5989, 2009.

VOLPINI ROSARIA

e-mail:
rosaria.volpini@unicam.it
view more info at:
https://docenti.unicam.it/pdett.aspx?ids=N&tv=d&UteId=363

short CV

VOLPINI ROSARIA

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