Maura Pellei | International School of Advanced Studies Unicam

short CV

bio

Prof. Maura Pellei : Academic achievements

2014 to date Associate Professor (General and Inorganic Chemistry) at School of Sciences and Technology, University of Camerino

2017 Qualification of Full Professor (BANDO D.D. 1532/2016) in “Fundaments of Chemical Sciences and Inorganic Systems”

2010-2014 Researcher (General and Inorganic Chemistry) at School of Sciences and Technology, University of Camerino

2010 PhD degree in Chemical Sciences at the School of Advanced Studies of the University of Camerino

2003 Degree in Chemistry at the University of Camerino, cum laude

1994-2010 Technical Assistant to Research Activity at the University of Camerino

1994 CNR-Fellowship for the Research project in “Asymmetric synthesis” at the Department of Chemistry, University of l’Aquila

1993 Degree in Biological Science at the University of l’Aquila, cum laude

Prof. Maura Pellei: Academic responsibilities

2014 to date Board of the Società Chimica Italiana, Sezione Marche

2013 to date Board of Doctorate Course in Chemical and Pharmaceutical Sciences and Biotechnology, Curriculum Chemical Sciences, of the School of Advanced Studies of the University of Camerino

2017-2020 Responsible for Internationalization activities, Chemistry Division, School of Science & Technology, UNICAM

2013-2017 Management Committee for the project COST SYRA3 n. TD1205

2012-2019 Board of the Rete Universitaria Italiana per l'Apprendimento Permanente (RUIAP)

2008-2011 Responsible for Life Long Learning for the University of Camerino (D.R. n. 80 del 28.02.2008)

2011-2018 Delegate of the Rector of the University of Camerino for Life Long Learning” (D.R. n. 3 del 03.11.2011)

Prof. Maura Pellei: Teaching Activities

2011 to date “General and Inorganic Chemistry and Laboratory”, Chemistry Degree (Class L-21), School of Science and Technology, UNICAM

2019 to date “Supramulecular and Bioinorganic Chemistry”, Chemistry and Advanced Chemical Methodologies (Class LM-54), School of Science and Technology, UNICAM

2014 to date “Laboratory I”, Biosciences and Biotechnology (Class L-2,13). School of Biosciences and Veterinary Medicine, UNICAM

2011-2019 “Chimica Bioinorganica”, Chemistry (MIUR Class L-21), School of Science & Technology, UNICAM

research topics

Her research interests can be summarized in the following topics: (a) development of new boron- and carbon-centered scorpionate ligands with C-, N-, O- and/or S-donor atoms; (b) evaluation of their coordination capabilities with main group and late transition metal ions; (c) bioinorganic and medicinal inorganic chemistry; (d) development of copper radiopharmaceuticals; (e) catalytic applications of copper complexes. Recently, the research effort mainly involves the synthesis of group 11 metal complexes and the evaluation of their biological activity as potential water-soluble anticancer compounds.

She is co-author of more than 110 publications, including 7 invited review articles on leading international journals, 2 patents, 1 Highlight and more than 180 presentations at scientific meetings or proceedings. She is Guest Editor of 5 Special Issues on international journals.

Bibliometric parameters: h-index = 32 (SCOPUS).

Granted research projects

UNICAM responsible for the project "Radiation-enhanced metal-based chemotherapy in the treatment of solid tumors" financed by AIRC "Call for Proposals 2016" (P.I. Prof. G. Cavaletti, 2016-2020).

Component of the Management Committee of SYRA3 (TD1205) COST project titled "Innovative methods in radiotherapy and radiosurgery using synchrotron radiation", chaired by Dr. A. Bravin, ESRF (2013-2015).

Principal Investigator for the 1st FAR proposal (University of Camerino, University Research Projects Year 2011-2012) titled "Design, synthesis and biological evaluation of novel chemical entities as potential anticancer drugs and for the control of the metastatic process”, financed by UNICAM.

PI for the scientific research project entitled “Metal systems supported by N-, C-, S- and/or P-donor systems with antitumor properties", financed by Sanofi-Aventis S.p.A (2011-2013).

selected publications

1) M. Pellei, V. Gandin, M. Marinelli, A. Orsetti, F. Del Bello, C. Santini and C. Marzano. “Novel triazolium based 11th group NHCs: synthesis, characterization and cellular response mechanisms”. Dalton Transactions, 44 (2015) 21041–21052. DOI: 10.1039/c5dt02934a

2) C. Santini, M. Marinelli and M. Pellei. “Boron-Centered Scorpionate-Type NHC-Based Ligands and Their Metal Complexes”. European Journal of Inorganic Chemistry, 15-16 (2016) 2312-2331. DOI: 10.1002/ejic.201600133

3) F. Tisato, C. Marzano, V. Peruzzo, M. Tegoni, M. Giorgetti, M. Damjanovic, A. Trapananti, A. Bagno, C. Santini, M. Pellei, M. Porchia, V. Gandin. “Insights into the cytotoxic activity of the phosphane copper(I) complex [Cu(thp)₄][PF₆]”. Journal of Inorganic Biochemistry, 165 (2016) 80-91. DOI: 10.1016/j.jinorgbio.2016.07.007

4) S. Tapanelli, A. Habluetzel, M. Pellei, L. Marchiò, A. Tombesi, A. Capparè and C. Santini. “Novel metalloantimalarials: Transmission blocking effects of water soluble Cu(I), Ag(I) and Au(I) phosphane complexes on the murine malaria parasite Plasmodium berghei”. Journal of Inorganic Biochemistry, 166 (2017) 1-4. DOI: 10.1016/j.jinorgbio.2016.10.004

5) V. Gandin, C. Ceresa, G. Esposito, S. Indraccolo, M. Porchia, F. Tisato, C. Santini, M. Pellei, C. Marzano. “Therapeutic potential of the phosphino Cu(I) complex (HydroCuP) in the treatment of solid tumors”. Scientific Reports, 7 (2017) 13936. DOI:10.1038/s41598-017-13698-1

6) C. Ceresa, G. Nicolini, S. Semperboni, V. Gandin, M. Monfrini, F. Avezza, P. Alberti, A. Bravin, M. Pellei, C. Santini, G. Cavaletti. “Evaluation of the profile and mechanism of neurotoxicity of water soluble [Cu(P)₄]PF₆ and [Au(P)₄]PF₆ (P = thp or PTA) anticancer complexes”. Neurotoxicity Research, 34 (2018) 93-108. DOI: 10.1007/s12640-018-9864-8

7) M. Porchia, M. Pellei, M. Marinelli, F. Tisato, F. Del Bello and C. Santini. "New insights in Au-NHCs complexes as anticancer agents”. European Journal of Medicinal Chemistry, 146 (2018) 709-746. DOI: 10.1016/j.ejmech.2018.01.065

Paper Highlighted on the European Journal of Medicinal Chemistry Front Cover, Issue 146, 25 February 2018. DOI: 10.1016/S0223-5234(18)30149-1

8) M. B. Morelli, C. Amantini, G. Santoni, M. Pellei, C. Santini, C. Cimarelli, E. Marcantoni, M. Petrini, F. Del Bello, G. Giorgioni, A. Piergentili and W. Quaglia. “Novel antitumor copper(II) complexes designed to act through synergistic mechanisms of action, due to the presence of an NMDA receptor ligand and copper in the same chemical entity”. New Journal of Chemistry, 42 (2018) 11878-11887. DOI: 10.1039/C8NJ01763H

9) M. Pellei, V. Gandin, C. Cimarelli, W. Quaglia, N. Mosca, L. Bagnarelli, C. Marzano and C. Santini. “Syntheses and biological studies of nitroimidazole conjugated heteroscorpionate ligands and related Cu (I) and Cu (II) complexes”. Journal of Inorganic Biochemistry, 187 (2018) 33-40. DOI: 10.1016/j.jinorgbio.2018.07.008

10) I. Fratoddi, I. Venditti, C. Battocchio, L. Carlini, S. Amatori, M. Porchia, F. Tisato, F. Bondino, E. Magnano, M. Pellei and C. Santini. “Conjugation of neutral and charged copper(I) complexes on hydrophilic gold nanoparticles: loading and release studies for biomedical applications”. Nanomaterials 9(5) (2019) 772. DOI: 10.3390/nano9050772

11) M. Pellei, V. Gandin, L. Marchiò, C. Marzano, L. Bagnarelli and C. Santini. “Syntheses and biological studies of Cu(II) complexes bearing bis (pyrazol-1-yl)- And Bis(triazol-1-yl)-acetato heteroscorpionate ligands”. Molecules 24(9) (2019) 1761. DOI: 10.3390/molecules24091761

12) M. Pellei, L. Bagnarelli, L. Luciani, F. Del Bello, G. Giorgioni, A. Piergentili, W. Quaglia, M. De Franco, V. Gandin, C. Marzano, C. Santini. “Synthesis and cytotoxic activity evaluation of new Cu(I) complexes of bis(pyrazol-1-yl) acetate ligands functionalized with an NMDA receptor antagonist”. International Journal of Molecular Sciences. 21(7) (2020) 2616. DOI: 10.3390/ijms21072616

PELLEI MAURA

e-mail:
maura.pellei@unicam.it
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https://docenti.unicam.it/pdett.aspx?ids=N&tv=d&UteId=322

short CV

PELLEI MAURA

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