Anna Maria Eleuteri

short CV

bio

ELEUTERI ANNA MARIA, born in Civitanova Marche (Italy) in 1965.

She graduated cum laude in Pharmacy at the University of Camerino in 1991 and from 1994 to 1996 she had a postdoc position at Mount Sinai School of Medicine (New York), Dept. of Pharmacology.

She is an Associate Professor in Clinical Biochemistry and Molecular Biology, University of Camerino (UNICAM)

She is the Vice Director of the International School of Advanced Studies and the coordinator of the PhD curriculum Life and Health Sciences (since 2014).

She coordinates the Quality Steering Committee for Human Resources in Research (since 2015) and she is advanced assessor of Research Institutions’ Human Resources Strategy for Researchers for the European Commission (since 2011).

She is the Rector’s delegate for Open Science (since 2019).

She is a member of the Società Italiana di Biochimica e Biologia Molecolare Clinica, Società Internazionale per la ricerca sui radicali liberi, Gruppo internazionale di ricerca su polifenoli.

A total of 82 peer-reviewed articles on journals with a wide scientific impact in the category Biochemistry and Molecular Biology (94% in Q1) and two book chapters are the results of her scientific contribution, which resulted in a H-index 26 (Scopus) and around 1700 citations.

ORCID ID: https://orcid.org/0000-0003-0461-1346.

research topics

RESEARCH TOPICS

1) functional and structural characterization of proteasomes purified from different bovine organs;

2) evaluation of the effects of oxidation induced by chemicals (peroxynitrite, H2O2) or by physical media (electromagnetic fields) and the effects of antioxidants on the structure and functionality of constitutive and interferon-gamma inducible 20S proteasomes isolated from bovine brain and thymus, respectively; the same studies are performed on cell lines in culture;

3) characterization of proteasomes present in brain of animal affected, and not, by prion diseases and in vitro analyses of prion proteins processing by isolated 20S proteasomes with the aim of understanding the potential role of the complex on the onset of these pathologies;

4) analysis of the impairment of proteolytic processes (ubiquitin-proteasome system and autophagy), involving the mechanisms included in their cross-talk, and effects of protein aggregates on the aetiology of neurodegenerative disorders, using proper cellular and animal models;

5) microbiota modulation by exogenous compounds (for example probiotics) able to affect gut-brain axis and the inflammatory pathway in the prevention and progression of neurodegenerations, using the triple transgenic mouse model of Alzheimer’s disease 3xTg-AD;

6) Study of effects of the oral administration of p62 engineered Lactobacilli as a therapeutic strategy in Alzheimer’s disease using the triple transgenic AD mouse model 3xTg-AD;

7) evaluation of the cytotoxic and proapoptotic effects of synthetic/semi-synthetic compounds containing Ruthenium (II) on cancer cells and their normal counterparts through the use of chromatographic, spectrophotometric/spectrofluorimetric methods and surface optical biosensor based analysis (enzymatic modulation, protein-binding, DNA-binding);

8) modulatory activities of plant derived dietary polyphenols on proteolytic (20S and 26S proteasomes and serine proteases) and redox enzymes involved in cholesterol biosynthesis (i.e. HMG-CoA reductase), besides their anti-oxidant function in cells and cell-free systems;

9) role of antinutraceutical agents from cereals, alpha-amylase/trypsin bifunctional inhibitors, on the onset of intestinal and extra-intestinal inflammatory disorders based on wheat consumption.

selected publications

Cuccioloni, M., Bonfili, L., Cecarini, V., Nabissi, M., Pettinari, R., Marchetti, F., Petrelli, R., Cappellacci, L., Angeletti, M., Eleuteri, A.M.

Exploring the Molecular Mechanisms Underlying the in vitro Anticancer Effects of Multitarget-Directed Hydrazone Ruthenium(II)–Arene Complexes

(2020) ChemMedChem, 15 (1), pp. 105-113 - Q1

Bonfili, L., Cecarini, V., Gogoi, O., Berardi, S., Scarpona, S., Angeletti, M., Rossi, G., Eleuteri, A.M.

Gut Microbiota Manipulation Through Probiotics Oral Administration Restores Glucose Homeostasis in a Mouse Model of Alzheimer's Disease

Neurobiol Aging 2019 - Q1

Cecarini, V., Cuccioloni, M., Bonfili, L., Ricciutelli, M., Valzano, M., Cappelli, A., Amantini, C., Favia, G., Eleuteri, A.M., Angeletti, M., Ricci, I.

Identification of a Killer Toxin from Wickerhamomyces anomalus with β-Glucanase Activity

Toxins, 11 (10) 2019 - Q1

Pettinari, R., Marchetti, F., Di Nicola, C., Pettinari, C., Cuccioloni, M., Bonfili, L., Eleuteri, A.M., Therrien, B., Batchelor, L.K., Dyson, P.J.

Novel osmium(II)-cymene complexes containing curcumin and bisdemethoxycurcumin ligands

Inorganic Chemistry Frontiers, 6 (9), pp. 2448-2457 2019 - Q1

Cappelli, K., Gialletti, R., Tesei, B., Bassotti, G., Fettucciari, K., Capomaccio, S., Bonfili, L., Cuccioloni, M., Eleuteri, A.M., Spaterna, A., Laus, F.

Guanylin, uroguanylin and guanylate cyclase-c are expressed in the gastrointestinal tract of horses

Frontiers in Physiology, 10 , art. no. 1237 2019 – Q1

Cuccioloni, M., Bonfili, L., Cecarini, V., Nabissi, M., Pettinari, R., Marchetti, F., Petrelli, R., Cappellacci, L., Angeletti, M., Eleuteri, A.M.

Exploring the Molecular Mechanisms Underlying the in vitro Anticancer Effects of Multitarget-Directed Hydrazone Ruthenium(II)–Arene Complexes

ChemMedChem 2019 - Q1

Pettinari, R., Marchetti, F., Di Nicola, C., Pettinari, C., Galindo, A., Petrelli, R., Cappellacci, L., Cuccioloni, M., Bonfili, L., Eleuteri, A.M., Guedes Da Silva, M.F.C., Pombeiro, A.J.L.

Ligand Design for N, O- or N, N-Pyrazolone-Based Hydrazones Ruthenium(II)-Arene Complexes and Investigation of Their Anticancer Activity

Inorganic Chemistry, 57 (22), pp. 14123-14133 2018 - Q1

Bonfili, L., Cecarini, V., Cuccioloni, M., Angeletti, M., Berardi, S., Scarpona, S., Rossi, G., Eleuteri, A.M. SLAB51 Probiotic Formulation Activates SIRT1 Pathway Promoting Antioxidant and Neuroprotective Effects in an AD Mouse Model

Molecular Neurobiology, 55 (10), pp. 7987-8000 2018 - Q1

Biagetti, M., Cuccioloni, M., Bonfili, L., Cecarini, V., Sebastiani, C., Curcio, L., Giammarioli, M., De Mia, G.M., Eleuteri, A.M., Angeletti, M.

Chimeric DNA/LNA-based biosensor for the rapid detection of African swine fever virus

Talanta, 184, pp. 35-41 2018 - Q1

Cuccioloni, M., Mozzicafreddo, M., Bonfili, L., Cecarini, V., Giangrossi, M., Falconi, M., Saitoh, S.-I., Eleuteri, A.M., Angeletti, M.

Interfering with the high-affinity interaction between wheat amylase trypsin inhibitor CM3 and toll-like receptor 4: In silico and biosensor-based studies

Scientific Reports, 7 (1), art. no. 13169 2017 – Q1

Bonfili, L., Cecarini, V., Cuccioloni, M., Angeletti, M., Flati, V., Corsetti, G., Pasini, E., Dioguardi, F.S., Eleuteri, A.M.

Essential amino acid mixtures drive cancer cells to apoptosis through proteasome inhibition and autophagy activation

FEBS Journal, 284 (11), pp. 1726-1737 2017 - Q1

Bonfili, L., Cecarini, V., Berardi, S., Scarpona, S., Suchodolski, J.S., Nasuti, C., Fiorini, D., Boarelli, M.C., Rossi, G., Eleuteri, A.M.

Microbiota modulation counteracts Alzheimer's disease progression influencing neuronal proteolysis and gut hormones plasma levels

Scientific Reports, 7 (1), art. no. 2426 2017 - Q1

Amantini, C., Farfariello, V., Morelli, C., Morelli, M.B., Marinelli, O., Nabissi, M., Santoni, M., Bonfili, L., Cecarini, V., Eleuteri, A.M., Santoni, G.

The TRPV1 ion channel regulates thymocyte differentiation by modulating autophagy and proteasome activity

Oncotargets, 8 (53), pp. 90766-90780. 2017 - Q1

Cuccioloni, M., Mozzicafreddo, M., Ali, I., Bonfili, L., Cecarini, V., Eleuteri, A.M., Angeletti, M.

Interaction between wheat alpha-amylase/trypsin bi-functional inhibitor and mammalian digestive enzymes: Kinetic, equilibrium and structural characterization of binding

(2016) Food Chemistry, 213, pp. 571-578 - Q1

Cuccioloni, M., Bonfili, L., Mozzicafreddo, M., Cecarini, V., Scuri, S., Cocchioni, M., Nabissi, M., Santoni, G., Eleuteri, A.M., Angeletti, M.

Mangiferin blocks proliferation and induces apoptosis of breast cancer cells: Via suppression of the mevalonate pathway and by proteasome inhibition

(2016) Food and Function, 7 (10), pp. 4299-4309 - Q1

Cecarini, V., Bonfili, L., Cuccioloni, M., Mozzicafreddo, M., Angeletti, M., Keller, J.N., Eleuteri, A.M.

The fine-tuning of proteolytic pathways in Alzheimer’s disease

(2016) Cellular and Molecular Life Sciences, 73 (18), pp. 3433-3451 - Q1

Cecarini, V., Bonfili, L., Cuccioloni, M., Keller, J.N., Bruce-Keller, A.J., Eleuteri, A.M.

Effects of Ghrelin on the Proteolytic Pathways of Alzheimer’s Disease Neuronal Cells

(2016) Molecular Neurobiology, 53 (5), pp. 3168-3178 - Q1

Valzano, M., Cecarini, V., Cappelli, A., Capone, A., Bozic, J., Cuccioloni, M., Epis, S., Petrelli, D., Angeletti, M., Eleuteri, A.M., Favia, G., Ricci, I.

A yeast strain associated to Anopheles mosquitoes produces a toxin able to kill malaria parasites

(2016) Malaria Journal, 15 (1), art. no. 21 - Q1

Cuccioloni, M., Bonfili, L., Mozzicafreddo, M., Cecarini, V., Pettinari, R., Condello, F., Pettinari, C., Marchetti, F., Angeletti, M., Eleuteri, A.M.

A ruthenium derivative of quercetin with enhanced cholesterol-lowering activity

(2016) RSC Advances, 6 (46), pp. 39636-39641 - Q1

Mozzicafreddo, M., Cuccioloni, M., Bonfili, L., Cecarini, V., Palermo, F.A., Cocci, P., Mosconi, G., Capone, A., Ricci, I., Eleuteri, A.M., Angeletti, M.

Environmental pollutants directly affect the liver X receptor alpha activity: Kinetic and thermodynamic characterization of binding

(2015) Journal of Steroid Biochemistry and Molecular Biology, 152, pp. 1-7 - Q1

Pettinari, R., Marchetti, F., Pettinari, C., Petrini, A., Skelton, B.W., White, A.H., Bonfili, L., Cuccioloni, M., Eleuteri, A.M.

Dinuclear (n6-arene) ruthenium(II) acylpyrazolone complexes: Synthesis, characterization and cytotoxicity

(2015) Journal of Organometallic Chemistry, 791, art. no. 19044, pp. 1-5 - Q1 (Material Chemistry)

Amantini, C., Morelli, M.B., Santoni, M., Soriani, A., Cardinali, C., Farfariello, V., Eleuteri, A.M., Bonfili, L., Mozzicafreddo, M., Nabissi, M., Cascinu, S., Santoni, G.

Sorafenib induces cathepsin B-mediated apoptosis of bladder cancer cells by regulating the Akt/PTEN pathway. The Akt inhibitor, perifosine, enhances the sorafenib-induced cytotoxicity against bladder cancer cells

(2015) Oncoscience, 2 (4), pp. 395-409 - Q2

ELEUTERI ANNA MARIA

e-mail:
annamaria.eleuteri@unicam.it
view more info at:
http://docenti.unicam.it/pdett.aspx